Aldol-condensation

Aldol-condensation THE ALDOL CONDENSATION REACTION:PREPARATION OF BENZALACETOPHENONES. Introduction: Benzaldehyde reacts with a ketone in the presence of a base to yield a alpha/beta-unsaturated ketone. This is an example of crossed aldol condensation reaction where the intermediate undergoes dehydration to produce a resonance stabilized unsaturated ketone. The mechanism of this mechanism is illustrated below in equation 1. The protocol for this reaction has 3 basic steps: 1)Running the reaction, 2)Isolation of crude product, and 3)Crystallization of 3-nitrobenzaldehyde. Please refer to the (Procedure) section below for an in depth description. Equation 1. Procedure: 1. RUNNING THE REACTION. 2. First, obtained .160 grams of 3-nitrobenzoaldehyde and it was placed in a 5ml conical vial. 3. Then .15ml of acetophenone and .80ml of 95% ethanol was added to the vial. 4. For safety the 5ml conical vial was placed in a 50ml beaker and then the contents in the 5ml vial were stirred for about 1 minute. 5. Next, .10ml of NaOH was added to the mixture and the contents were stirred again until it solidified into a slimy mixture. 6. ISOLATION OF CRUDE PRODUCT. 7. In order to isolate the crude product 2ml of ice-water was added and the mixture was then transferred to a small beaker containing 3ml of ice-water. 8. The contents were then product, volume, 3-nitrobenzaldehyde, yield, melting, mass, acetophenone, /, vial, reaction, point, moles, ml, crude, percent, order, total, test, stirred, obtained, mixture, methanol, ketone, isolated, impurities, grams, ethanol, contents, conical, amount, added, 5ml, 15ml, table, section