The_Human_Genome_Project

The Human Genome Project The Human Gene Project There are a number of ways to investigate the structure, function and evolution of the human genome. These include examining the morphology of normal and abnormal chromosomes, constructing maps of genomic landmarks, following the genetic transmission of phenotypes and DNA sequence variations, and characterizing thousands of individual genes. To this list we can now add the elucidation of the genomic DNA sequence, albeit at 'working draft' accuracy. The current challenge is to weave together these disparate types of data to produce the information infrastructure needed to support the next generation of biomedical research. The ultimate goal of the Human Genome Project is to produce a single continuous sequence for each of the 24 human chromosomes and to define the positions of all genes. The working draft sequence described by the International Human Genome Sequencing Consortium was constructed by melding together sequence segments resulting from over 20,000 large-insert clones. Over the next few years, draft quality sequence will be steadily replaced by more accurate data. The National Center for Biotechnology Information has developed a system for rapidly regenerating the genomic sequence and gene annotation as sequences of the original clones are revised. Undoubtedly, others will apply a variety sequence, human, genes, gene, draft, protein, genomic, genome, working, positions, mouse, been, sequences, lmx1b, information, family, being, useful, splicing, species, search, related, predicted, map, example, chromosome, another, adam, way, support, region, project, omim, important, further, cytogenetic