Sickle_Cell_Anemia

Sickle Cell Anemia Sickle cell anemia is an autonomic recessive disorder in which abnormal hemoglobin leads to chronic hemolytic anemia along with periodic episodes of pain. The mutation in hemoglobin sickle cell anemia is a blood condition primarily affecting people of African ancestry. It has been researched and proven that the error in the hemoglobin gene results from a genetic mutation that occurred many thousands of years ago in people in parts of Africa, the Mediterranean basin, the Middle East, and India. It is associated with being immune to malaria, a parasitic blood disease that is carried and contracted by infected mosquitoes. Since malaria is mostly found in hot, moist areas in West Africa and the Mediterranean, people originating from that area produced an immunity to towards malaria, but with consequences (Bloom). The individual will not contract malaria because the mutation in his/her genes quickly fight off the disease by changing the shape and composition make-up of the blood cell so the parasites will not be able to survive in it (Van Cleve, Lemerond). The consequence of this is that because the individual’s blood cells mutate and become misshaped, becoming “moon crescent” or “sickle-shaped”, the blood cells sickle, cell, anemia, hemoglobin, blood, gene, children, one, cells, red, people, fetal, child, trait, hydroxyurea, therapy, patients, genes, disease, two, production, prevent, however, given, drugs, cure, condition, complications, years, pain, normal, chance, vessels, time