Pollution_Prevention,_Management,

Pollution Prevention, Management, This presentation focuses on evaluation and implementation of pollution prevention during the process development phase for a new drug. Pollution prevention initiatives are best incorporated during the process development phase, in which a process is scaled form the laboratory to the pilot plant. Evaluation of pollution prevention initiatives is iterative, and part of the process evolution. Many process changes driven primarily by yield or productivity gains can also lead to reduced potential pollution (although such changers are not "pollution prevention initiatives", per se), which provides added incentive to successfully implement these process changes. For any drug process, pollution prevention initiatives should be evaluated during each development phase, and, if appropriate, incorporated into the process. The first phase involves analysis of the Biological and chemical pathways to the final drug. The original, process, pollution, prevention, phase, initiatives, during, development, changes, drug, processes, policy, pilot, look, laboratory, incorporated, facility, evaluation, environmental, yield, william, waste, virginia, undemonstrated, typically, tool, time, successfully, study, solvent, simulation, significantly, should, second, se, scaled